Thermogravimetric analysis, or TGA, examines the change in the mass of a substance as a function of temperature, time of heating, or both. This technique may be of more value and provide more meaningful information than a loss on drying determination, usually carried out at a fixed temperature for a fixed time at imprecise atmospheric conditions. TGA can, under most circumstances, distinguish surface-absorbed moisture or solvent from that occluded in a crystal formation or lattice, as well as losses due to thermally-induced degradation.
Measurements can be carried out in controlled atmospheres to reveal interactions with a drug substance, between drug substances, and between active substances and additives, excipients, or packaging materials.
When requesting TGA analysis services, please use our Thermal Analysis Request Form.