Optical activity is the property of some substances, including certain active pharmaceutical ingredients, enabling the rotation of a beam of plane-polarized light. Polarimetry, the measurement of optical activity, is often the only convenient means for distinguishing optically active isomers from each other, and therefore provides an important methodology for the determination of identity and purity.
Robertson Microlit Laboratories can provide measurements of optical rotation for liquid substances, or specific rotation for solutions of solid substances at five discrete wavelengths under controlled temperature conditions. Typically, 10 - 20 mg of sample is required for this determination, depending upon your analytical requirements.
When requesting rotation analyses, please use our FT-IR/UV-VIS/ROTATION Request Form.