Bioavailability
Bioavailability
Analyses at Robertson Microlit help customers establish guidelines leading
to In Vivo testing of a drug. This unique combination of bioavailability
analyses can only be found at Robertson Microlit.Solubility
Robertson Microlit offers Solubility Studies of organic compounds. The solubility measurements of the compound are made in any number of solvents, at any given temperature, and for any length of time, to meet the customers' specific needs.
The study is UV-based, therefore the compound must have an absorbing UV/VIS chromophore.
We provide the solubility of the compound in mg/ml for each solvent. A reference UV spectrum, and all data are stored to disk and archived for future reference.
Minimum sample requirement: Amount of sample required depends on solubility guidelines set forth by the client and the volume of the stock solution to be used.
pKa
Robertson Microlit provides ionization constants-pKa values in aqueous solution. Using proprietary methods, we can determine up to five pKa values for a multiprotic compound.
Minimum
sample requirement:
0.02 mmol if pKa = 4 to 9
0.10 mmol if pKa < 4 or >9
Log D (pH 7.4)
The distribution coefficient, Log D, at physiological pH is a good measure of the oral absorption of a drug. Our distribution profile is a graph of the distribution of all forms of the compound between the 0.15 M aqueous sodium chloride and octanol over a full range of pH values.
Robertson Microlit provides the Log D (pH 7.4) and the Distribution Profile by potentiometric titration.
Minimum sample
requirement:
0.02 mmol if pKa = 4 to 9
0.10 mmol if pKa < 4 or >9
Log Pn / Log Pi
Robertson Microlit provides partition and distribution coefficients for acids, bases, and amino acids by potentiometric titration. The method provides the partition coefficients of the ions, Log Pi, as well as that of the neutral compound, Log Pn.
Minimum sample
requirement:
0.02 mmol if pKa = 4 to 9
0.10 mmol if pKa < 4 or >9
